My personal experience is also based on a long PAP. Mine is 6-1/4 left, 1-5/16 up. However, my primary layout is 97-1/2 Drilling Angle x 3-3/8 Pin to PAP x 41 Angle to VAL. Those numbers place the Pin precisely 3-3/8 from my PAP and 6-3/4 from the center of my thumbhole. For most balls, symmetrical or asymmetrical, that produces the most track flare and ball reaction of any layout without a balance hole. The 6-3/4 from Pin to center of thumbhole is significant because it places the largest hole in the ball directly in the side of the core which increases the drilled Int. Diff and Total Diff.
My preference these days is not to vary the layout, but to vary balls and surfaces. If I was a staffer, and limited to certain balls, I might be more inclined to vary layouts, but I find it unnecessary with the huge variety of balls available. And, I am confident knowing I am using the strongest layout for my release specs, along with a familiar hook shape. Btw, that layout is not for everybody, as it has the potential to flare over the thumb for bowlers with over 300 RPMs.
Years ago, when I first started drilling my own equipment, I experimented with a huge number of different balls and layouts until I started to see a pattern emerge what scored best for me. It was around that time I purchased Blueprint and it confirmed what I knew intuitively. If I had only purchased it sooner, it would have saved me thousands of dollars.
PBA (2014-2015): $850
Heavy: Nano, HyperCell, Eternal Cell
Medium: IQ Tour, Tour SiC, Tag
Light: Spare+, Tank, Rebel Tank
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